Built in 1774, Medway.
Broken up in 1810.
- 1799 Capt. W. MITCHELL, North Sea. Flagship of Vice Ad. Sir Andrew MILLER during the expedition against Holland.
- 1800 Capt. J. OUGHTON, Sheerness.
- 1801 Capt. James WALKER.
With Lord NELSON's squadron which attacked the Danish defensive line at Copenhagen on 3 April 1801. She was heavily engaged for four and a half hours with two of the enemy's heaviest block ships, moored about two cables' length from each other, and a battery of 14 guns and 2 howitzers between them at about three cables distance.
At one point in the battle, with only five guns working, Lieut. William LAYMAN manned and replaced the whole larboard battery on the lower deck while under fire from the enemy.
ISIS had heavy losses: Mr Daniel LAMOND, master; Mr Henry Long, Lieutenant of marines; Messrs, George M'KINLAY and Thomas RAM, midshipmen and Lieut. Grant, Rifle Corps, were killed and Lieut. Richard CORMACK and Messrs. Ruben PAIN, Simon FRAZER and Charles JONES, midshipmen, were wounded. From the crew 22 seamen, 3 marines and 2 soldiers of the rifle corps were killed and 69 seamen, 13 marines and 2 soldiers were wounded.
- Capt. William NOWELL, 07/1801.
When he returned from the Baltic in GLATTON in July he was ordered to take command of ISIS, then in dock, transfer his people from GLATTON, and fit her out immediately. Although he had only a few seamen among his crew, ISIS was re-rigged in nine days and ready fore service at the Nore. ISIS joined Lord NELSON's squadron off the French coast. Capt. Thomas Masterman HARDY, 08/1801. She arrived in Portsmouth from the Downs on 26 February 1802. She sailed from there on 21 April for Falmouth to receive the Duke of Kent on board for passage to Gibraltar. She returned to Portsmouth on 29 May.
- During the peace of Amiens ISIS was the flagship of Vice Ad. GAMBIER in Newfoundland.
On her passage across the Atlantic she encountered a hurricane which threw her on to her beam ends. She lost her top-masts and jib-boom and had all her sails blown to shreds. The mizzen mast had to be cut away and the main was about to follow when she fortunately fell off the wind, partially righted, and then showed her stern to the wind.
- 1802 Capt. BRACE
- 1803 Capt. W. G. LOBB, 01/1803, Spithead in January.
- On 13 March she was ordered to sail immediately to Hoseley Bay under the command of Lieut. LAROCHE, Capt. LOBB being absent on leave. Two days later she was still at Spithead and on the 18th. she received orders for the Downs. She finally sailed for the North Sea on the 27th. to be stationed off Goree as the flagship of Rear Ad. Edward THORNBROUGH.
- On the evening of Wednesday 27 April ISIS fell in with UTRECHT, Capt. ROGERS, and the Rear Admiral shifted his flag to her.
- ISIS returned to Portsmouth on the afternoon of 29 April to be stored and victualled before returning to Newfoundland again as the Flagship of Vice Ad. GAMBIER.
- On 8 June she embarked more than 200 troops and on the evening of the 11th. Lord GAMBIER arrived from London to hoist his flag in her. She was paid on the 14th. and sailed on the evening tide of 23 June for Newfoundland.
- ISIS returned to Portsmouth with a convoy from Newfoundland on 15 November. She brought in with her the French ship CAROLINE from San Domingo, prize to ISIS, and the UNION and MARIA from the West Indies which she had retaken.
- On 12 February 1804 ISIS sailed from Portsmouth with the outward bound East India fleet with a fine breeze at N. E. She anchored off St Helen's during the night and sailed again in the morning. The convoy passed Plymouth on the 15th.
- The Boatswain of ISIS, Mr J. MORGAN was dismissed the service as an officer and ordered to serve as a seaman by a court martial on board GLADIATOR on 2 May 1804.
- 1805 Capt. J. A. OMMANNEY,at Spithead in February. The Downs in April to reinforce the ships watching six Dutch line-of-battle-ships in the Texel and the French flotilla at Boulogne, then to Newfoundland as Flagship of Vice Ad. Sir Erasmus GOWER.
- 1806 Capt. William CUMING, 01/1806. Early in 1806 Sir Erasmus appointed ISIS's first Lieutenant, Mr Abraham LOWE, to be magistrate of the island. A position he held until ISIS, under the command of Capt. John LAUGHARNE, returned with Vice Ad. John HOLLOWAY in April 1807.
- 1809 Capt. Donald M'LEAD, 01/1809. Capt. Hon. Granville PROBY, 09/1809, Channel.